Buses leave every 15 minutes from the Terminal San Borja, near the Central Station and the one and a half hour journey costs only $7. Seats are allocated, the buses are clean, very comfortable with reclining seats , seem to be properly maintained and are bang on time - we were so impressed.
There are several companies operating this route, all charge the same fare and would appear to offer the same efficient service.
The terminal in Valparaiso is on Av Pedro Montt, near the Congress Building and Plaza O'Higgins.
No need to make a reservation, just arrive at the terminal or Pajaritos station and go to the counter of the company you prefer and buy your ticket for the bus with the next available departure.
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