We drove to the Anchorage Resort and Yacht Club in Key Largo on Saturday. It was a 16 hr drive from Virginia. The rest areas in Florida have good night security so whenever we felt tired or sleepy, we pulled into and slept for an hour or so.
We avoided traffic by driving mostly at night. By the time we reached our resort, we were very tired and decided to take an easy night. The resort is really nice; it has a huge bedroom and a full kitchen. We can see the bay from our balcony.
You can stop by a service plaza for breakfast. There are a couple plazas which are near to entrance and exit to the Turnpike (there are a lot of toll fees along the turnpike) . They are the only rest areas which sell food, the others just have restrooms. We got crepes at one of them, they were very good.