The Laboratory Brewing Company, San Antonio

Known as "The Lab" by locals, this hot spot was the first true brewpub in the city. It serves up great burgers and such for dinner, but it's the after-hours atmosphere that draws the crowds. Four proprietary beer varieties are brewed on site to complement the fully stocked bar. Locals and visitors revel in hanging out on the breezy patio and enjoying the live music. Get there early if you want a table and any semblance of service, because it gets packed later in the evening.