Istanbul is such a diverse city that it's almost impossible to split it up into definable districts. The only real distinction that can be made is between the European and Asian sides, which are separated by the Bosphorus Strait. Stretching from the Black Sea, straddling across the Bosphorus, touching the Sea of Marmara, Istanbul, with an estimated population of between 10-13 million, has become a city of unlimited scope.
Sultanahmet
Most people who come to Istanbul land feet first in Sultanahmet. This peninsula (known as Sarayburnu) juts out into the Bosphorus, the Golden Horn and the Sea of Marmara. Rich in history, it's a natural magnet to millions of tourists every year. The home of Topkapi Serayi (Topkapi Palace) , Ayasofya (Hagia Sophia) , the Blue Mosque (Sultan Ahmet Mosque) , Yerebatan Serayi (Yerebetan Basilica Cistern) , and the At Meydani(Hippodrome), Sultanahmet is filled to the brim with hotels, restaurants, cafes, bars, rug stores and cheesy souvenir shops, as well as a plethora of fascinating museums, mosques, markets and historical sites. The main drag, Divan Yolu, is the heartbeat of the area, and there are hundreds of tiny back streets and alleyways to explore the history of the old city. The labyrinthine Kapaliçarsi (Grand Bazaar /Covered Bazaar) near Beyazit University is also on this street. Sultanahmet can be a little intimidating as it truly caters to only tourists. (Read: you'll have to learn quickly not to respond to "Hey! Are you American/English /German /Spanish/Italian /French?") One impressive thing about Sultanahmet is that the businessmen each seem to speak every major European language, so if your Turkish isn't up to par, don't fret.
Eminönü
Situated right on the waterfront on the Golden Horn, Eminönü is the end of the tramline. It is generally buzzing with activity during the day, with street peddlers selling you things you never even knew you wanted. The vast Misir Çarsi (Egyptian Spice Bazaar) is the main feature of Eminönü Square and Mimar Sinan's Yeni Camii (New Mosque) is a familiar landmark with its minarets standing tall above the general chaos. Ferries to the Asian side and the Princes Islands leave from the huge docks lining the shore, where you can stop by and have a balikekmek (fresh fish sandwich) while you wait for your vessel. The Sirkeci Train Station is also here: all trains to and from Europe begin and end their journeys here.
Beyoglu / Taksim
A veritable symphony of Occident and Orient, Beyoglu is the pulsating heartbeat of Istanbul's day and nightlife. Istiklal Caddesi -- a paved thoroughfare perpetually swarming with Istanbul's colorful hoi polloi -- is at the hub of the metropolis while a maze of narrow winding lanes filled with funky cafes, soulful bars, continental restaurants, historic cinemas, prominent theaters and exclusive shops shoot off in all directions around it. Taksim Square, featuring the impressive Monument to the Republic, leads the way into Beyoglu's bohemian open-air museum, past the Greek Orthodox Aya Triade Church and the French Consulate. A quaint old tramway carries passengers past the Rumeli Han, Çiçek Pasaji, Cite de Pera, Atlas Pasaji, Galatasaray Lisesi, and several elegant consulates. Every year the International Istanbul Film Festival , International Istanbul Music Festival , International Istanbul Theater Festival and the International Istanbul Jazz Festival are held here and in nearby districts. Beyoglu, which has been the traditional home of Istanbul's gay community, hosts various other annual events, including the Bosphorus Festival, Roxy Music Days, Aksanat Jazz Festival and the Blues Festival.
Tünel
This is undoubtedly Istanbul's Bohemian Quarter, which not so long ago was perceived as a bad part of town, with its dark deserted streets and creepy abandoned buildings. However, the area has undergone tremendous development in recent years. Tiny cafes, live music venues, and open-air restaurants and bars now quietly coexist with art galleries, antique bookshops and music stores.
Karaköy
Around the first century BC, there was a tiny village situated on the mini peninsula of the Golden Horn where the modern suburb of Karaköy stands today. These days, Karaköy is a bustling port with a lively fish market, a hectic ferry terminal and a shady nightlife; an intriguing landscape at the mouth of the Golden Horn. Scores of locals fish from the Galata Bridge and an array of vendors peddle all kinds of goods along the sidewalks. A vast underground marketplace where you can buy electrical appliances and guns, among other things, provides not-so-safe passage under the busy road to the entrance of Tünel. Up the hill is Bankalar Caddesi, an historical area filled with banks, art galleries and do-it-yourself stores. All visiting international cruise ships dock in Karaköy.
Galata
The Genoese-built Galata Tower is the most central point here. The renowned Turkish film Istanbul Beneath My Wings tells the story of Hazarfen Çelebi, who flew from this tower with a home-made pair of wings. The main street, Galip Dede Caddesi, is a hub of activity with shops selling musical instruments and antique books, and you'll also find a good dose of tiny local restaurants. The Whirling Dervishes have a home here at the Galata Mevlevihanesi (Dervish Lodge) ; the Goethe Institute provides locals with a good dose of culture and art; and there are countless mosques, churches and synagogues hidden away in obscure side streets.
Golden Horn
The most interesting part of the Golden Horn district comprises of the stretch of land between Eminönü and Ayvansaray, up as far as Eyüp. The Selimiye Mosque, the Fethiye Mosque and St. Steven's Church grace the shoreline while the Kariye Müzesi (Chora Church) and Mihrimah Mosque are further inland. The old city walls start at Ayvansaray and snake overland to Yedikapi.
Besiktas and Ortaköy
Besiktas -- which is actually dismally devoid of places to help you paint the town red -- is at the center of the three-way fork that leads up the hill to Levent. Ortaköy, on the other hand, is a bustling suburb on the waterfront. Bubbling over with cafes, bars, restaurants and tea houses, this area is a popular weekend hangout for locals. Ortaköy's back streets are buzzing with handicraft stalls filled with trinkets and souvenirs on summer weekends. This part of town is renowned for its mosque, church and synagogue within close quarters of one another. The Bosphorus Bridge spans the waterway overhead.
Bosphorus: Arnavutköy to Sariyer
The Bosphorus shore on the European side is lined with Ottoman-style mansions, high society hangouts and fish restaurants. There is only one main road and it follows the shoreline all the way to Zekariyeköy, a popular weekend getaway for the citybound.
Sea of Marmara Coast: Kumkapi to Yediküle
Kumkapi is a distinctly touristy area filled with over-priced fish restaurants and not much else besides views of the sea. The coast road heads out toward the airport past the old city walls and Yediküle Fortress.
Asian Side & Bosphorus: Kadiköy to Anadolu Hisari
Kadiköy is a quieter version of Beyoglu with a more subdued atmosphere. The tiny cobbled lanes are filled with restaurants, cafes, bars, cinemas and shops, but most importantly, residents! The Asian side of town is where most Istanbulites live; you'll have a harder time with no Turkish language skills here, but it's worth it to pop over on the ferry and experience a more relaxed way of life. The coast road snakes past Üsküdar, a pretty suburb with plenty of fine examples of Mimar Sinan's work, including the Mihrimah Sultan and Semsi Pasa Mosques. Selimiye Barracks (where Florence Nightingale worked during the Crimean War) is up on the hill. Heading toward Anadolu Hisari, the road winds along the shoreline (which is less built up than that of the European side). There are plenty of parks and trees, outdoor cafes and restaurants and a string of historical buildings to explore including Beylerbeyi Palace , Kuleli Mosque, Kuleli Naval Officer's Training School, Küçüksu Park and Kiosk and Anadolu Hisari.
Princes Islands
There are four islands in the Sea of Marmara that attract crowds escaping the summer heat: Büyükada, Heybeliada, Kinaliada and Burgazada. Ferries leave from Sirkeci, Kadiköy and Bostanci regularly. There are no cars on the islands -- the transport here is limited to horse-drawn carriages. Each island offers plenty of places to eat and sleep, and there are Greek monasteries atop the hills of Büyükada and Heybeliada.
Harbiye-Nisantasi-Sisli-Mecidiyeköy-Levent
The Military Museum in Harbiye is a good landmark from which to begin exploring Istanbul's business life. Nisantasi is the central shopping district, while Sisli is strictly a business district that goes all the way to Levent and beyond to Maslak. There is now an underground metro linking Taksim with Fourth Levent.
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Vegetarian
A new trend in Turkey, vegetarianism has had a slow beginning but there has been some progress. Nuh'un Ambari, Nature and Peace , Badehane , and Zencefil in Beyoglu are just a few of the hot spots for herbivores on the European side. Also try Hercai whilst in Kadiköy on the Asian side.
Street Food
Europeans and Asians alike seem to love to feast on the streets, buying delicious snacks from vendors wheeling carts. Istanbul is no different: a midnight snack could include stuffed mussels (midye dolma), a fried mussel sandwich, meatballs made with barley (icli köfte), or even raw meat (cig köfte). Gözleme (filled pancake) is a favorite lunch-time snack, along with baked potatoes filled with anything you want (kumpir), and even plain old chicken and rice. Breakfast could consist of simit (bread rings with sesame seeds), pogaca (cheese- or potato-filled pastry), catal (a cracker-like snack), or a variety of sweets dripping with syrup, honey, and/or rosewater.
Drinking
A nasty side effect of the rapidly changing cityscape is that drinking dens come and go with frustrating frequency, and the bar you were at last night may not be there tomorrow; but fear not, as it's not hard to find a new one!
Sultanahmet
More famous for its historical sites and pushy salesmen, Sultanahmet has a few good cafes where you can sit and write your postcards home. Spend some time at the Rumeli Cafe for excellent people-watching. Try Cheers for cheap beer or Sultan Pub for terrace seating.
Beyoglu
The cafe-bar scene changes faster than most people can blink. "Here today, gone tomorrow" seems to be the motto. However, there are a few hangers-on like Dulcinea , Madrid, Pia, Kaktüs Cafe , and Kemanci . The distinction between "cafe" and "bar" has become very blurred recently and most places do a combination of both. Cafes include Yagmur Cybercafe , Lounge, Cafe Frappe , Kafe Cute , (a popular gay hangout), and 35mm (located in the Fitas Cinema complex). The best nightclubs -- all thumping out techno until the wee hours -- are Switch , Milk, Taxim She, and Orange. Live music venues Roxy and Babylon are the hottest hits in town at the moment. Bar Bahçe and Neo are excellent gay bars, while the best gay clubs are Prive and Club 14. Some of the finest wine bars in the world have popped up recently: check out Pano Wine Bar , Sarabi Wine Bar , Vareli, or Sappho.
Kadiköy
Less manic than Beyoglu, Kadiköy has its own style of nightlife. Rock bar Karga fills up fast with students, and the Belfast Pub and Shaft do live music. If it's coffee you're after, Cafe Antre is mellow and female-friendly and Mosquito Cafe is fun.
Other Notable Watering Holes
The Wall in Ortaköy fills fast with leather-clad rockers and boppers, and another great option is the up-market Coco Pazzo in Arnavutköy.
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