Wonderful location, great place
We've spent 4 nights at the Comfort Suites City Centre. During the week, enjoy a free continential breakfast (which includes hard-boiled eggs, which is not common in that type of breakfast). Quiet rooms, nice pool and gym, but best of all, it's close to everything. The Eaton Centre and Dundas subway station are only a few blocks away, so you can park your car at the hotel (indoor parking @ $18/day) and visit the city by foot. It's about 15 minutes from the financial district, the Hockey Hall of Fame, etc.
There's also a Dominion grocery 1 block away.
The neibourhood is probably not the richest one, but people don't bother with you so it's just fine. But I wouldn't recommend for a woman to walk alone in those streets late at night.
The Concierge lady was very nice and we were able to book some attractions through her and save on the admission price.
We will definitely go back to this hotel on our next trip to Toronto.